Publications scientifiques

Roy, R.; Yihong Cao, Y.; Kaltner, H.; Kottari, N.; Shiao, T. C.; Belkhadem, K.; André, S.; Manning, J. C.; Murphy, P. V.; Gabius, H.-J. Teaming up synthetic chemistry and histochemistry for activity screening in galectin-directed inhibitor design. Histochem. Cell Biol., 2017, 147, 285-301.

Nguyen, P. T.; Sharma, R.; Rej, R.; De Carufel, C.-A.; Roy, R.; Bourgault, S. Low generation anionic dendrimers modulate islet amyloid polypeptide self-assembly and inhibit pancreatic b-cell toxicity. RSC Adv., 2016, 6, 76360-76369.

Roy, R.; Murphy, P. V.; Gabius, H.-G. Multivalent Carbohydrate-Lectin Interactions: How Synthetic Chemistry Enables Insights Into Nanometric Recognition. Molecules, 2016, R21, 629.

Goyard, D.; Shiao, T. C.; Fraleigh, N. L.; Vu, H.-Y.; Lee, H.; Diaz Mitoma, F.; Le, H.T.; Roy, R. Expedient synthesis of functional single-component glycoliposomes using thiol-yne Chemistry. J. Mat. Chem. B, 2016, 4, 4227-4233.

Shiao, T. C.; Rej.R.; Rose, M.; Pavan.G. M.; Roy, R.. Synthesis of Dense and Chiral Dendritic Polyols Using Glyconanosynthon Scaffolds. Molecules 2016, 21, 448.

Goyette-Desjardins, G.; Calzas, C.; Shiao, T. C.; Neubauer, A.; Kempker, J.; Roy, R.; Gottschalk, M.; Segura, M. Protection against Streptococcus suis serotype 2 infection using a capsular polysaccharide glycoconjugate vaccine. Inf. Immun., 2016, 84, 2059-2075.

Van Calsteren, M-R.; Goyette-Desjardins, G.; Gagnon, F.; Okura, M.; Takamatsu, D.; Roy, R.; Gottschalk, M.; Segura, M. Explaining the Serological Behavior of Streptococcus suis Serotypes 1 and 1/2 from their Capsular Polysaccharide Structure and Biosynthesis. J. Biol. Chem., 2016, 291, 8387-8398.

Sharma, R.; Zhang, I.; Shiao, T. C.; Maysinger, D.; Roy, R. Low generation Polyamine Dendrimers Bearing Flexible Tetraethylene Glycol as nanocarriers for plasmids and siRNA. Nanoscale, 2016, 8, 5106-5119.

Abbassi, L.; Chabre, Y. M.; Kottari, N.; Arnold, A. A.; André, S.; Josserand, J.; Gabius, H.-J.; Roy, R.; R.Multifaceted Glycodendrimers With Programmable Bioactivity Through Convergent, Divergent, and Accelerated Approaches Using Polyfunctional Cyclotriphosphazenes. Polym.Chem., 2015, 6, 7666-7683.

Swanson, M. D.; Boudreaux, D. M.; Salmon, L.; Chugh, J.; Winter, H. C.; Meagher, J. L.;  André, S.; Murphy, P. V.; Oscarson, S.; Roy, R.; King, S.; Kaplan, M. H.; Goldstein, I. J.; Tarbet, E. B.; Hurst, B. L.; Smee, D. F.; de la Fuente, C.; Hoffmann, H.-H.; Xue, Y.; Rice, C. M.; Schols, D.; Garcia, J. V.; Stuckey, J. A.; Gabius, J.-H.; Al-Hashimi, H. M.; Markovitz, D. M. Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity. Cell, 2015, 163, 746-758.

Rauthu, S. R.; Shiao, T. C.; André, S.; Miller, M. C.; Madej, É.; Mayo, K.; Gabius, H.-J.; Roy, R. Defining the potential of aglycone modifications for affinity/selectivity enhancement against medically relevant lectins: synthesis, activity screening, and HSQC-based NMR analysis. ChemBioChem, 2015, 16, 126-139.

Zhang, S.; Moussodia, R.-O.; Murzeau, C.; Sun, H.-J.; Klein, M. L.; Vértesy, S.; André, S.; Roy, R.; Gabius,  H.-J.; Percec, V. Dissecting molecular aspects of cell interactions using glycodendrimersomes with programmable glycan presentation and engineered human lectins. Angew. Chem. Int. Ed., 2015, 54, 4036-4040.

Sharma, R.; Zhang, I.; Abbassi, L.; Rej, R.; Maysinger, D.; Roy, R. Fast track dendrimer synthesis using microwave assisted accelerated onion peel approach. Polym. Chem., 2015, 6, 1436-1444.

Roy, R.; Shiao, T. C. Glyconanosynthons as powerful scaffolds and building blocks for the rapid construction of multifaceted, dense and chiral dendrimers. Chem Soc. Rev., 2015, 44, 3924-3941.

Solís,D.; Bovin,N. V.; Davis,A. P.; Jiménez-Barbero, J.; Romero, A.; Roy, R.; Smetana Jr, K.; Gabius, H.-J. A guide into glycosciences: how chemistry and biochemistry cooperate to crack the sugar code. Biochim. Biophys. Acta, 2015, 1850, 186-235.

Sharma, R.; Kottari, N.; Chabre, Y. M.; Abbassi, L.; Shiao, T. C.; Roy, R. Highly versatile convergent/divergent “onion peel” strategy toward potent multivalent glycodendrimers. Chem Commun. 2014, 50, 13300-13303.

Talaga, M. L.; Fan, N.; Fueri, A.L.; Brown, R. K.; Chabre, Y. M.; Bandyopadhyay, P.; Roy, R.; Dam, T. K. The significant other half of glycoconjugate: contributions of scaffolds to lectin-glycoconjugate interactions. Biochemistry, 2014, 53, 4445-4454.

Sharma, R.; Naresh, K.; Chabre, Y. M.; Rej, R.; Saadeh, N. K.; Roy, R., Onion Peel” Dendrimers: A Straightforward Synthetic Approach Towards Highly Diversified Architectures. Polym. Chem. 2014, 5, 4321-4331.

Vanwetswinkel, S.; Volkov, A. N.; Sterckx, Y. G. J.; Garcia-Pino, A.; Buts, L.; Vranken, W. F.;  Bouckaert, J.; Roy, R.; Wyns, L.; van Nuland, N. Study of the structural and dynamic effects in the FimH adhesion upon heptyl a-D-mannopyranoside binding. J. Med. Chem. 2014, 57, 1416-1427.

Naresh, K.; Shiao, T. C.; Chabre, Y. M.; Roy, R. Efficient and Rapid Synthesis of Multifunctional Dendrimers Using Orthogonal Thiol-ene and SN2 Reactions. Chem. Commun., 2014, 50, 1983-1985.

Zhang, S.; Moussodia,  R.-O.; Sun, H.-J.; Leowanawat, P.; Muncan, A.; Nusbaum, C. D.; Chelling, K. M.; Heiney, P. A.; Klein, M. L.; André, S.; Roy, R.; Gabius, H.-J.; Percec, V. Mimics of Biological Membranes with Programmable Glycan Ligands Self-Assembled from Amphiphilic Janus Glycodendrimers. Angew. Chem Int. Ed., 2014, 53, 10899-10903.

Roos, G.; Wellens, A.; Touaibia, M.; Geerlings, P.; Roy, R.; Wyns, L.; Bouckaert, J., Validation of reactivity descriptors to assess the aromatic stacking within the tyrosine gate of FimH, ACS Med. Chem. Lett., 2013, 4, 10851090.

Roy, R.; Shiao, T. C.; Rittenhouse-Olson, K. Glycodendrimers : Versatile Tools for Nanotechnology. Braz. J. Pharm. Sci. 2013, 49, 85-108

Gingras, M.; Chabre, Y. M.; Roy, M.; Roy, R. How do multivalent glycodendrimers benefit from sulfur chemistry? Chem. Soc. Rev. 2013, 42, 4823-4841.

Renaudet, O.; Roy, R. Multivalent scaffolds in glycoscience: an overview. Chem. Soc. Rev., 2013, 42, 4515-4517.

Percec, V.; Leowanawat, P.;  Sun, H.-J.; Kulikov, O.; Nusbaum, C. D.; Tran, T. M.; Bertin, A.; Wilson, D. A.; Peterca, M.; Zhang, S.; Kamat, N. P.; Vargo, K.; Moock, D.; Johnston, E. D.; Hammer, D. A.; Pochan, D. J.; Chen, Y.; Chabre, Y. M.; Shiao,T. C.; Bergeron-Brlek, M.; André, S.; Roy, R.; Gabius, H.-J.; Heiney, P. A.; Modular Synthesis of Amphiphilic Janus Glycodendrimers and their Self-Assembly into Glycodendrimersomes and Other Complex Architectures with Bioactivity to Biomedically Relevant Lectins. J. Am. Chem. Soc. 2013, 135, 9055-9077.

Chabre, Y. M.; Roy, R. Multivalent glycoconjugate syntheses and applications using aromatic scaffolds. Chem. Soc. Rev. 2013, 42, 4657-4708.